Dead hearts transplanted into living patients in Australia
SYDNEY: In a breakthrough, a team of doctors,
including an Indian-origin surgeon, on Friday said they have successfully
performed the world’s first heart transplant in Australia using a “dead heart”,
a major development that could save many lives.
The procedure, using hearts that had stopped beating,
has been described as a “paradigm shift” that will herald a major increase in
the pool of hearts available for transplantation. It is predicted the
breakthrough will save the lives of 30 per cent more heart transplant patients.
Until now, transplant units have relied solely on
still-beating donor hearts from brain-dead patients. However, the team at the lung transplant unit
of St Vincent's Hospital here announced they had transplanted three heart
failure patients using donor hearts that had stopped beating for 20 minutes.
The first patient who received a heart Michelle
Gribilas said she felt a decade younger and was now a "different
Cardiothoracic surgeon Kumud Dhital, who performed the
transplants with hearts donated after circulatory death (DCD), said he
"kicked the air" when the first surgery was successful.
It was possible thanks to new technology, he said. “The
incredible development of the preservation solution with this technology of
being able to preserve the heart, resuscitate it and to assess the function of
the heart has made this possible, he said.
Hearts are the only organ that is not used after the
heart has stopped beating — known as donation after circulatory death.
Beating hearts are normally taken from brain-dead
people, kept on ice for around four hours and then transplanted to patients.
The novel technique used in Sydney involved taking a
heart that had stopped beating and reviving it in a machine known as a ‘heart
in a box’. The heart is kept warm, the heartbeat is restored and a nourishing
fluid helps reduce damage to the heart muscle.
Gribilas, 57, who was suffering from congenital heart
failure. She had the surgery more than two months ago. “Now I’m a different
person altogether,” she said. :I feel like I’m 40 years old — I’m very lucky.” There
have since been a further two successful operations.
Prof Peter MacDonald, head of St Vincent's heart
transplant unit, said: “This breakthrough represents a major inroad to reducing
the shortage of donor organs.”
It is thought the heart-in-a-box, which is being
tested at sites around the world, could save up to 30 per cent more lives by
increasing the number of available organs. The breakthrough has been welcomed
around the world. The British Heart Foundation described it as a